MPOX OUTBREAK INVESTIGATION AMONG HIV-POSITIVE PATIENTS IN YOGYAKARTA CITY, INDONESIA, 2024
DOI:
https://doi.org/10.17501/26138417.2025.8111Keywords:
mpox, zoonosis, outbreak, HIVAbstract
In July 2022, WHO declared mpox as a Public Health Emergency of International Concern (PHEIC) due to its rapid spread and caused outbreaks worldwide. In December 2023, an outbreak of mpox infections occurred in Yogyakarta City. The investigation aimed to explore sociodemographic and risk factors of the outbreak -and recommend control measures. A descriptive study was conducted from December 6, 2023, to March 2, 2024. Active case finding through direct interviews with the cases followed by contact tracing. Cases defined as individuals presenting with skin rashes include single or multiple lesions on the anogenital area or other areas of the body, for which the rash is not caused by other diseases and confirmed through diagnostic tests using Polymerase Chain Reaction (PCR). Two confirmed cases of mpox were found without an epidemiological link with zero death. Both cases were 35 and 34 years-old males with a history of HIV-positive under regular ARV treatment, experiencing fever, lesions, anogenital pain, fatigue, and diarrhea. One of them had syphilis (50%). Risk factors include sexual orientation as a man who has sex with men (MSM) and bisexual, with no history of travelling abroad. During treatment, they were instructed to self-isolation along with close contacts, including sexual partners. There has been local transmission of mpox in Yogyakarta City, especially among key populations. Health authorities should increase awareness, enhance surveillance, case detection and health promotion to limit the spread of the disease.
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Abdullahi, M., Nas, A., & Bello, B. (2024). Epidemiology, Virology, Transmission, Symptoms and Treatment of Mpox: A Review. Academic Journal of Life Sciences, 19–24. https://doi.org/10.32861/ajls.92.19.24
Abdulrahim, A., Gulumbe, B. H., Idris, I., Abubakar, T. M., Sobur, K. A., Lawal, A. I., & Shehu, A. (2025). Strengthening global health preparedness amid Mpox spread in Africa. Discover Public Health, 22(1), 9. https://doi.org/10.1186/s12982-025-00392-1
Aloqaily, H., Abdurhman Alnafea, R., Abdullah Alotaibi, S., Bakir, M., Bin Nafisah, S., & Mzahim, B. (2024). Mpox Preparedness and Response 2024: Position Statement of The Disaster Management Experts Club. The Journal of Medicine, Law & Public Health, 5(1), 514–526. https://doi.org/10.52609/jmlph.v5i1.163
D´Angelo, P., Loureiro, C., Jaspe, R., Sulbarán, Y., Rodríguez, L., Alarcón, V., Monsalve, I., García, J. M., Zambrano, J. L., Rangel, H., Pujol, F. H., D´Angelo, P., Loureiro, C., Jaspe, R., Sulbarán, Y., Rodríguez, L., Alarcón, V., Monsalve, I., García, J. M. Pujol, F. H. (2024). Epidemiological and virological characterization of mpox cases in Venezuela during the multinational 2022-2023 outbreak. Investigación Clínica, 65(4), 445–453. https://doi.org/10.54817/ic.v65n4a05
Hossain, A., Monem, M. A., Rahman, M., & Raza, R. (2025). Mpox (monkeypox): A comprehensive updated of current epidemic evidence. Science in One Health, 4, 100100. https://doi.org/10.1016/j.soh.2024.100100
Humphreys, G. (2024). Mpox and stigma. Bulletin of the World Health Organization, 102(12), 848–849. https://doi.org/10.2471/BLT.24.021224
Indonesia Ministry of Health (2023). Guidelines for Prevention and Control of Mpox 2023. Indonesia Ministry of Health. (Indonesian)
Ladnyj, I. D., Ziegler, P., & Kima, E. (1972). A human infection caused by monkeypox virus in Basankusu Territory, Democratic Republic of the Congo. Bulletin of the World Health Organization, 46(5), 593–597.
Mukadi-Bamuleka, D. (2024). Towards a coordinated, integrated, contextualized response to the ongoing Mpox emergency in the Democratic Republic of the Congo. Annales Africaines de Medecine, 17(4), Article 4. https://doi.org/10.4314/aamed.v17i4.1
Naga, N. G., Nawar, E. A., Mobarak, A. A., Faramawy, A. G., & Al-Kordy, H. M. H. (2025). Monkeypox: A re-emergent virus with global health implications – a comprehensive review. Tropical Diseases, Travel Medicine and Vaccines, 11(1), 2. https://doi.org/10.1186/s40794-024-00237-w
Nelwan, E. J., Tanadi, C., Pajala, F. B., Stella, M. M., Tandarto, K., Supranoto, Y. T. N., Kalaij, A. G. I., Adiwinata, R., Nainggolan, L., Lie, K. C., Masyeni, S., & Sinto, R. (2024). Re-Emerging Trend of Mpox Infection: The Indonesia’s Experience and Review. Acta Medica Indonesiana, 56(3), Article 3.
Nuzzo, J. B., Borio, L. L., & Gostin, L. O. (2022). The WHO Declaration of Monkeypox as a Global Public Health Emergency. JAMA, 328(7), 615–617. https://doi.org/10.1001/jama.2022.12513
Mitjà, O., Alemany, A., Marks, M., Mora, J. I. L., Rodríguez-Aldama, J. C., Silva, M. S. T., Herrera, E. A. C., Crabtree-Ramirez, B., Blanco, J. L., Girometti, N., Mazzotta, V., Hazra, A., Silva, M., Montenegro-Idrogo, J. J., Gebo, K., Ghosn, J., Vázquez, M. F. P., Prado, E. M., Unigwe, U., … Paredes, M. T. (2023). Mpox in people with advanced HIV infection: A global case series. The Lancet, 401(10380), 939–949. https://doi.org/10.1016/S0140-6736(23)00273-8
Oza, S., Chen, F., Selser, V., Clougherty, M. M., Dale, K. D., Iberg Johnson, J., Brock-Fisher, T., Seung, K. J., & Bourdeaux, M. (2023). Community-Based Outbreak Investigation And Response: Enhancing Preparedness, Public Health Capacity, And Equity: Commentary examines Community-Based Outbreak Investigation And Response, a local public health strategy developed during the COVID-19 pandemic. Health Affairs, 42(3), 349–356. https://doi.org/10.1377/hlthaff.2022.01257
Paterson, A., Cheyne, A., Tulunay, H., Orkin, C., Nutland, W., Dunning, J., Stolow, J., Gobat, N., Olliaro, P., Rojek, A., & Group, O. S. A. E. (2025). Mpox stigma in the UK and implications for future outbreak control. Research Square. https://doi.org/10.21203/rs.3.rs-5704043/v1
Pesonel, E., Laouénan, C., Guiraud, L., Bourner, J., Hoffmann, I., Molino, D., Tardivon, C., Bachelet, D., Mentré, F., Amstutz, A., Merson, L., Rojek, A., Cervantes Gonzalez, M., Antinori, A., Castagna, A., Nozza, S., Pourcher, V., Libois, A., Dunning, J., … for the Mpox ObServAtIonal Cohort (MOSAIC) Study Group. (2025). Clinical Characterization and Outcomes of Human Clade IIb Mpox Virus Disease: A European Multicenter Mpox Observational Cohort Study (MOSAIC). Clinical Infectious Diseases, ciae657. https://doi.org/10.1093/cid/ciae657
Russell, A., Siddiq, M., Fitzpatrick, C., & Richardson, D. (2024). Anorectal Mpox in men who have sex with men associated with sexually transmitted co-infections: A case series. Sexually Transmitted Infections, 100(1), 52–53. https://doi.org/10.1136/sextrans-2023-055906
Sahoo, O. S., Sapam, D., Ajmeria, S., Aidasani, H., Dhar, R., & Karmakar, S. (2025). Immunobiology of Mpox Infection and Its Management: Experience From Developing Nations. Reviews in Medical Virology, 35(1), e70015. https://doi.org/10.1002/rmv.70015
Shabil, M., Gaidhane, S., Roopashree, R., Kaur, M., Srivastava, M., Barwal, A., Siva Prasad, G. V., Rajput, P., Syed, R., Dev, A., Kundra, D., Yappalparvi, A., Satapathy, P., Zahiruddin, Q. S., Kumar, H., Sah, R., & Bushi, G. (2025). Association of HIV infection and hospitalization among mpox cases: A systematic review and meta-analysis. BMC Infectious Diseases, 25(1), 102. https://doi.org/10.1186/s12879-025-10512-6
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Copyright (c) 2025 Boy Shandy, Amira Nada Fatikha, Anandi Iedha Retnani, Solikhin Dwi Ramtana, Risalia Reni Arisanti
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